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ClearHealth  
ClearHealth is a medical software suite for clinics large and small but with many features and enchancements for practices with multiple facilities. ClearHealth includes modules for Scheduling, Billing, EMR, HIPAA Compliant Security, Accounts Receivable, Document Managment and much more.

Eclipse Open Healthcare Framework  
The Eclipse Open Healthcare Framework (OHF) is a project within Eclipse formed for the purpose of expediting healthcare informatics technology. The project is composed of extensible frameworks and tools which emphasize the use of existing and emerging standards in order to encourage interoperable open source infrastructure, thereby lowering integration barriers. We currently provide tools and Frameworks for HL7, IHE, Terminology, Devices, and Public Healthcare Maintenance.

FreeB  
FreeB was the first GPL Medical Billing Engine. FreeB supports the HCFA 1500 and X12 837p 4010a formats.

MirrorMed  
MirrorMed is a free and open source EHR and practice management system written in PHP. MirrorMed is a web-based application that is capable of running a healthcare practice. MirrorMed shares code with FreeMED, and OpenEMR.

Mirth  
Mirth is an open source cross-platform HL7 interface engine that enables bi-directional sending of HL7 messages between systems and applications over multiple transports. By utilizing an enterprise service bus framework and a channel-based architecture, Mirth allows messages to be filtered, transformed, and routed based on user-defined rules.


OpenMRS
A community-developed, open-source, enterprise electronic medical record system framework intended to aid resource-constrained healthcare environments.

OpenVista  
OpenVista is the open-source version of VistA, which is an enterprise grade health care information system developed by the U.S. Department of Veterans Affairs (VA) and deployed at nearly 1,500 facilities worldwide.

PatientOS
PatientOS is a free clinical information management system designed for hospitals and healthcare practitioners.This software is for physicians, nursing, pharmacy, the laboratory and eventually all hospital departmenets. An extensive sofware architecture has been designed to create the highest quality system

WorldVistA EHR  
WorldVistA EHRTM  is an open source electronic health record (EHR) based on the highly acclaimed VistA system of the United States Department of Veterans Affairs (VA). The foundation for WorldVistA EHR was developed as part of the VistA-Office project, a collaborative effort funded by the Centers for Medicare & Medicaid Services (CMS), an agency of the Department of Health and Human Services (DHHS). The overall goal of the VistA-Office EHR (VOE) project was to encourage the broader adoption and effective use of EHRs among physicians by making a robust, flexible EHR solution alternative available.

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